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Do Large Clinical Trials Adequately Consider Individual Patient Physiology? Debating The RELIEF Study

By Michael Keane, BMBS, FANZCA and Shashikanth Manikappa, MD, DNB, FANZCA
February 21, 2019

Patient safety requires a well-informed debate about the rationale of large, randomized controlled trials (RCTs) and whether, by their very nature, they can adequately consider the unique physiology of every individual patient. 

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WAKE-UP Time for Thrombolysis in Acute Stroke?


By Martina McGrath, MD
October 30, 2018

MRI thrombolysis for stroke of unknown time of onset

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Prior studies have suggested a particular pattern may be seen on an MRI of the brain in the early hours following stroke onset; a visible ischemic lesion on diffusion-weighted imaging along with the lack of a hyperintense signal in the same area on fluid-attenuated inversion recovery (FLAIR). The benefit of aggressive stroke intervention in patients with the combination of unknown time of symptom onset and this particular signal mismatch on MRI brain scans is unknown. Continue reading “WAKE-UP Time for Thrombolysis in Acute Stroke?”

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By Olivier Lucar
October 16, 2018

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By Connor Emdin
September 26, 2018

SCOTT NELLES Land Speed RacerMinichamps 1 12 Scale Diecast 125 706635 Porsche 917 Watkins Glen 6H 1970 LennepAUTOart 1970 Chevrolet Corvette C3 1 18 Diecast CarVintage Dinky 25D2 - Petrol Tanker Pre War - Green In Collecta Box Continue reading “Use of Guideline-Recommended Medical Therapy in Patients with Heart Failure”

Restrictive versus Liberal Fluid Therapy in Abdominal Surgery

By Connor Emdin
August 28, 2018

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Epinephrine in Out-Of-Hospital Cardiac Arrest: Increased Survival but at What Cost?

By Martina McGrath, MD
August 8, 2018

It is estimated that 1 in every 7.5 people in the US will die of sudden cardiac death.Brooklin Models 1 43 Scale BRK16 015 - 1936 Dodge Van - Tobacco Livery Survival following out-of-hospital cardiac arrest has increased in recent years, from 10.2% in 2006, to 12.4% in 2015.1 However, only 9% of those surviving to hospital discharge were classified as having good functional status. Therefore, significant long-term neurologic impairment is a common outcome of cardiac arrest. Continue reading “Epinephrine in Out-Of-Hospital Cardiac Arrest: Increased Survival but at What Cost?”

Cervical Cancer Screening Using HPV Testing Alone: Are We There Yet?

1 Ford 1910s A Metal Model Vintage Hot T 12 Rod 64 Drag Race Car 24 Sport 18

By Martina McGrath, MD
July 18, 2018

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Spider Swb California 250Gt Ferrari 1959 CAR34A 43 1 BBR Matsuda Yoshiho Per.Car 3cf40dgau51126-Toys & Games

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MR ,AMOR 28100

Item specifics

Condition: New Marke: Bbr
MPN: Nicht zutreffend Brand: Bbr
EAN: Nicht zutreffend Herstellernummer: Nicht zutreffend
Ferrari 250Gt California Swb Spider 1959 Per.Car Yoshiho Matsuda BBR 1 43 CAR34A

Dulaglutide in Type 2 Diabetes: Do GLP-1 agonists delay progression of diabetic nephropathy?

Kyosho Mini Car KSR18010W samurai 1 18 Lexus IS 350 F Sports White Completed

By Connor Emdin
June 27, 2018

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Procalcitonin-Guided Antibiotic Therapy in Lower Respiratory Tract Infection: Is It Safe?


By Martina McGrath, MD
June 5, 2018

IMBRIMA INBRIMA MATCHBOX No. 75 ALFA CARABO B081Corgi 1 50 Scale 18003 - Scammell Contractor x2, Nicolas Girder Trailer - Wynns CMC 1 18 - Mercedes W165 1939 Sieger von Tripolis

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Vintage 1950's Marusan NASH RAMBLER Station Wagon Car Plastic Model

By Lea Borgi, MD
May 16, 2018

AUTOart 1 18 Lamborghini Countach 25th Anniversary (Red) finished productRare Die Mold Resin Citroen Cx Ambulance Car 1 43 Heco Models UAuto Torque No.3 1 43 Scale - 1934 Ford Squire 1.5 Litre Hood Closed - bluee Continue reading “Does Menu Labeling Lead to Healthier Food Choices?”