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Do Large Clinical Trials Adequately Consider Individual Patient Physiology? Debating The RELIEF Study

By Michael Keane, BMBS, FANZCA and Shashikanth Manikappa, MD, DNB, FANZCA
February 21, 2019

Patient safety requires a well-informed debate about the rationale of large, randomized controlled trials (RCTs) and whether, by their very nature, they can adequately consider the unique physiology of every individual patient. 

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WAKE-UP Time for Thrombolysis in Acute Stroke?

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By Martina McGrath, MD
October 30, 2018

MRI thrombolysis for stroke of unknown time of onset


Prior studies have suggested a particular pattern may be seen on an MRI of the brain in the early hours following stroke onset; a visible ischemic lesion on diffusion-weighted imaging along with the lack of a hyperintense signal in the same area on fluid-attenuated inversion recovery (FLAIR). The benefit of aggressive stroke intervention in patients with the combination of unknown time of symptom onset and this particular signal mismatch on MRI brain scans is unknown. Continue reading “WAKE-UP Time for Thrombolysis in Acute Stroke?”

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By Olivier Lucar
October 16, 2018

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By Connor Emdin
September 26, 2018

NIB Scruff A Luvs bluee 2018 HOT CHRISTMAS Toy Little Live Pets Rescue PetNEW Whale Shark Medium Size COLORATA Stuffed ToySigikid 38368, Girl And Boy, Plush Fox Patchwork SweetyGIANT GREEN PYTHON Snake Boa Constrictor - Soft Toy Snake - 200cm Continue reading “Use of Guideline-Recommended Medical Therapy in Patients with Heart Failure”

Restrictive versus Liberal Fluid Therapy in Abdominal Surgery

By Connor Emdin
August 28, 2018

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Epinephrine in Out-Of-Hospital Cardiac Arrest: Increased Survival but at What Cost?

By Martina McGrath, MD
August 8, 2018

It is estimated that 1 in every 7.5 people in the US will die of sudden cardiac death.Super Soft Giant Panda Bears Stuffed Animals Set by Exceptional Home Zoo - 18 - Survival following out-of-hospital cardiac arrest has increased in recent years, from 10.2% in 2006, to 12.4% in 2015.1 However, only 9% of those surviving to hospital discharge were classified as having good functional status. Therefore, significant long-term neurologic impairment is a common outcome of cardiac arrest. Continue reading “Epinephrine in Out-Of-Hospital Cardiac Arrest: Increased Survival but at What Cost?”

Cervical Cancer Screening Using HPV Testing Alone: Are We There Yet?

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By Martina McGrath, MD
July 18, 2018

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Dulaglutide in Type 2 Diabetes: Do GLP-1 agonists delay progression of diabetic nephropathy?

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By Connor Emdin
June 27, 2018

Seat Pets (Bull Dog by Jay at Play – As Seen on TV - Kids Seat Belt Car TravelLelly (LELL4) 692249 Lelly Baby Panda Bear Soft Toy, 20 cm, Multi-colorJellycat Small Bashful Chocolate Brown Bunny Rabbit Soft Toy Comforter Baby RareHansa Baby Tapir 6838 Plush Soft Toy Sold by Lincrafts Established 1993 22 LARGE CUDDLE TIME PUPPY DOG SOFT CUDDLY TOY TEDDY BEAR GINGER CREAM NEXT CAT

Procalcitonin-Guided Antibiotic Therapy in Lower Respiratory Tract Infection: Is It Safe?

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By Martina McGrath, MD
June 5, 2018

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Emmy the Giraffe -Large toy (25cm) + Medium toy (20cm) +keyring bag charm (15cm)

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By Lea Borgi, MD
May 16, 2018

Keel Plush Soft Toys Cuddly Animal Kids Cat Dog Dolphin Owl Lion Penguin GiraffeJellycat Medium Lewis Bunny RabbitDOOM Eternal Cacodemon Plush 6 Official ID Bethesda Demon Plushie Figure Continue reading “Does Menu Labeling Lead to Healthier Food Choices?”