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Do Large Clinical Trials Adequately Consider Individual Patient Physiology? Debating The RELIEF Study

By Michael Keane, BMBS, FANZCA and Shashikanth Manikappa, MD, DNB, FANZCA
February 21, 2019

Patient safety requires a well-informed debate about the rationale of large, randomized controlled trials (RCTs) and whether, by their very nature, they can adequately consider the unique physiology of every individual patient. 

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WAKE-UP Time for Thrombolysis in Acute Stroke?

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By Martina McGrath, MD
October 30, 2018

MRI thrombolysis for stroke of unknown time of onset

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Prior studies have suggested a particular pattern may be seen on an MRI of the brain in the early hours following stroke onset; a visible ischemic lesion on diffusion-weighted imaging along with the lack of a hyperintense signal in the same area on fluid-attenuated inversion recovery (FLAIR). The benefit of aggressive stroke intervention in patients with the combination of unknown time of symptom onset and this particular signal mismatch on MRI brain scans is unknown. Continue reading “WAKE-UP Time for Thrombolysis in Acute Stroke?”

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By Olivier Lucar
October 16, 2018

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By Connor Emdin
September 26, 2018

TSR Marvel Super Heroes Marvel Super Heroes - Advanced Set Box FairFantasy Flight Games Star Wars Legion Galactic Empire AT-STStar Wars Armada Core Set - Brand New BStar Wars Legion Core Set Continue reading “Use of Guideline-Recommended Medical Therapy in Patients with Heart Failure”

Restrictive versus Liberal Fluid Therapy in Abdominal Surgery

By Connor Emdin
August 28, 2018

Star Wars Miniatures WoTC Boba Fett, Bounty HunterStar Wars X-Wing the Force Awakens Core Set1 1200 renaissance generic - galleys as photo - ships (31177)10mm classical selucid - battle group 64 figures - inf (35213) Continue reading “Restrictive versus Liberal Fluid Therapy in Abdominal Surgery”

Epinephrine in Out-Of-Hospital Cardiac Arrest: Increased Survival but at What Cost?

By Martina McGrath, MD
August 8, 2018

It is estimated that 1 in every 7.5 people in the US will die of sudden cardiac death.THE ONE RING RPG Lot Oaths of the Riddermark & Rivendell - Cubicle 7 Survival following out-of-hospital cardiac arrest has increased in recent years, from 10.2% in 2006, to 12.4% in 2015.1 However, only 9% of those surviving to hospital discharge were classified as having good functional status. Therefore, significant long-term neurologic impairment is a common outcome of cardiac arrest. Continue reading “Epinephrine in Out-Of-Hospital Cardiac Arrest: Increased Survival but at What Cost?”

Cervical Cancer Screening Using HPV Testing Alone: Are We There Yet?

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By Martina McGrath, MD
July 18, 2018

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Dulaglutide in Type 2 Diabetes: Do GLP-1 agonists delay progression of diabetic nephropathy?

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By Connor Emdin
June 27, 2018

15mm classical persian - achaemenid 12 Cavalry - cav (A1245)15mm dark ages norman - milites 12 figures - cav (23644)15mm medieval swiss - allied knights 12 figures - cav (33730)15mm napoleonic haitian - 27 rebels - inf (91494) Yu-Gi-Oh Cybernetic Horizon Booster Display (24) German Version

Procalcitonin-Guided Antibiotic Therapy in Lower Respiratory Tract Infection: Is It Safe?

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By Martina McGrath, MD
June 5, 2018

15mm renaissance turkish - sipahis 12 figures - cav (23275)15mm WW1 british - infantry & MGs 24 figures - inf (16272) Changeling The Lost Dancers in the Dusk HC

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15mm WW2 german - section 27 figures - inf (32295)

By Lea Borgi, MD
May 16, 2018

20mm 19th century prussian - regiment 24 figures - inf (28505)20mm napoleonic french - plastic carabiniers 18 cavalry - cav (18073)25mm 19th century british - officers 3 figures - command (22901) Continue reading “Does Menu Labeling Lead to Healthier Food Choices?”