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Do Large Clinical Trials Adequately Consider Individual Patient Physiology? Debating The RELIEF Study

By Michael Keane, BMBS, FANZCA and Shashikanth Manikappa, MD, DNB, FANZCA
February 21, 2019

Patient safety requires a well-informed debate about the rationale of large, randomized controlled trials (RCTs) and whether, by their very nature, they can adequately consider the unique physiology of every individual patient. 

12x DL1 C05 samurai ronin oriental fighters citadel gw games workshop pre-slottaBattlefleet Gothic Eldar Shadow Class Cruiser cCitadel CC1 Gothic Horror Adventurer Personalities Warhammer Figure Call Cthulhu  Continue reading “Do Large Clinical Trials Adequately Consider Individual Patient Physiology? Debating The RELIEF Study”

WAKE-UP Time for Thrombolysis in Acute Stroke?

25mm renaissance turkish - dellis 10 figures - cav (23260)

By Martina McGrath, MD
October 30, 2018

MRI thrombolysis for stroke of unknown time of onset

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Prior studies have suggested a particular pattern may be seen on an MRI of the brain in the early hours following stroke onset; a visible ischemic lesion on diffusion-weighted imaging along with the lack of a hyperintense signal in the same area on fluid-attenuated inversion recovery (FLAIR). The benefit of aggressive stroke intervention in patients with the combination of unknown time of symptom onset and this particular signal mismatch on MRI brain scans is unknown. Continue reading “WAKE-UP Time for Thrombolysis in Acute Stroke?”

25mm roman era gauls - heavy 10 figures - cav (29198)

By Olivier Lucar
October 16, 2018

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25mm roman era roman - cavalry 16 cavalry - cav (10701)

By Connor Emdin
September 26, 2018

Warhammer 40k Death Guard Plague Marines GWS 43-55 NIBWarhammer Age of Sigmar Chaos Chosen GW Resin NIBWarhammer AoS Vampire Lord on Nightmare Steed (Count Mannfred) GW Resin NIBWH40K SCENERY , OUTPOST BASTION, BASTION ONLY, PAINTED Continue reading “Use of Guideline-Recommended Medical Therapy in Patients with Heart Failure”

Restrictive versus Liberal Fluid Therapy in Abdominal Surgery

By Connor Emdin
August 28, 2018

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Epinephrine in Out-Of-Hospital Cardiac Arrest: Increased Survival but at What Cost?

By Martina McGrath, MD
August 8, 2018

It is estimated that 1 in every 7.5 people in the US will die of sudden cardiac death.28mm ACW confederate - civil war 1 gun 1 limber artillery - art (21749) Survival following out-of-hospital cardiac arrest has increased in recent years, from 10.2% in 2006, to 12.4% in 2015.1 However, only 9% of those surviving to hospital discharge were classified as having good functional status. Therefore, significant long-term neurologic impairment is a common outcome of cardiac arrest. Continue reading “Epinephrine in Out-Of-Hospital Cardiac Arrest: Increased Survival but at What Cost?”

Cervical Cancer Screening Using HPV Testing Alone: Are We There Yet?

28mm Napoleonic Dutch Imperial Guard Infantry, ProPainted

By Martina McGrath, MD
July 18, 2018

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25mm biblical   assyrian - cavalry 16 cavalry - inf (11414)

Dulaglutide in Type 2 Diabetes: Do GLP-1 agonists delay progression of diabetic nephropathy?

2nd Edition Brigade Fire And Fury ACW Wargames Rules

By Connor Emdin
June 27, 2018

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Procalcitonin-Guided Antibiotic Therapy in Lower Respiratory Tract Infection: Is It Safe?


By Martina McGrath, MD
June 5, 2018

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NEW Lord of the Rings Warhammer Guritz & Gothmog’s Enforcer lot x

By Lea Borgi, MD
May 16, 2018

Theoden Foot and Mounted Rohan Lord New On Sprue SBG GW LOTR Lord of the RingsWarhammer LotR; Saruman mounted. Hobbit White Council or Isengard wizardGames Workshop Mordheim Mordheim Witch Hunter Warhammer Metal Figure Painted C3 Continue reading “Does Menu Labeling Lead to Healthier Food Choices?”