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Do Large Clinical Trials Adequately Consider Individual Patient Physiology? Debating The RELIEF Study

By Michael Keane, BMBS, FANZCA and Shashikanth Manikappa, MD, DNB, FANZCA
February 21, 2019

Patient safety requires a well-informed debate about the rationale of large, randomized controlled trials (RCTs) and whether, by their very nature, they can adequately consider the unique physiology of every individual patient. 

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WAKE-UP Time for Thrombolysis in Acute Stroke?

25mm ECW english - civil war artillery 2 guns - art (14774)

By Martina McGrath, MD
October 30, 2018

MRI thrombolysis for stroke of unknown time of onset

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Prior studies have suggested a particular pattern may be seen on an MRI of the brain in the early hours following stroke onset; a visible ischemic lesion on diffusion-weighted imaging along with the lack of a hyperintense signal in the same area on fluid-attenuated inversion recovery (FLAIR). The benefit of aggressive stroke intervention in patients with the combination of unknown time of symptom onset and this particular signal mismatch on MRI brain scans is unknown. Continue reading “WAKE-UP Time for Thrombolysis in Acute Stroke?”

25mm ECW parliament - heavy 10 figures - cav (33212)

By Olivier Lucar
October 16, 2018

Flintloque catalucian dark elf artillery (as photo) {16} (20652)Gas Lamp Alley VICTORIAN COVERED MARKET STATION MDF scale Building 28mm G051HISTORICAL BATTLELINES - OLD DOMINION GAMEWORKS - 1600-1800Item scifi 40k - chaos death guard 6 plague marines metal - (19434)Maison Forte Combo Set28mm Laser cut MDF Building Terrain N12825mm ECW royalist - civil war royalist cuirassiers 7 figs cav - cav (22342)

25mm foundry ancient egyptian archers 20 infantry (10668)

By Connor Emdin
September 26, 2018

Napoleonic Metal Wargaming 20 Figures 20mm 1.72 23rd Fusillier ( Royal Welsh)PAINTED 28MM PERRY REBEL INFANTRYREGIMENTAL FIRE AND FURY - WARGAMES RULES - NEWSkaven rat men 30 (15115) warhammer fantasy sigmar Continue reading “Use of Guideline-Recommended Medical Therapy in Patients with Heart Failure”

Restrictive versus Liberal Fluid Therapy in Abdominal Surgery

By Connor Emdin
August 28, 2018

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Epinephrine in Out-Of-Hospital Cardiac Arrest: Increased Survival but at What Cost?

By Martina McGrath, MD
August 8, 2018

It is estimated that 1 in every 7.5 people in the US will die of sudden cardiac death.25mm medieval english - royal hunting party 11 figures - baggage (33485) Survival following out-of-hospital cardiac arrest has increased in recent years, from 10.2% in 2006, to 12.4% in 2015.1 However, only 9% of those surviving to hospital discharge were classified as having good functional status. Therefore, significant long-term neurologic impairment is a common outcome of cardiac arrest. Continue reading “Epinephrine in Out-Of-Hospital Cardiac Arrest: Increased Survival but at What Cost?”

Cervical Cancer Screening Using HPV Testing Alone: Are We There Yet?

25mm napoleonic austrian - line (old school) 24 figures - inf (35471)

By Martina McGrath, MD
July 18, 2018

25mm Vikings Ancient Battles 100+ mixed metal figuresBloodbowl Dwarf Giants blitzer pro paintedEpic Warhammer 40k lot of chaos khorne bloodletter flesh houndGames Workshop Warhammer Skeeton Warriors Regiment NIB Factory Sealed 25mm napoleonic british - 3 guns & crews - art (35428)

- union ACW 15mm american (16009) inf - figures 45 infantry war civil 3cf40azct82484-Toys & Games

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Item specifics

Type: Historical
15mm ACW   union - american civil war infantry 45 figures - inf (16009)

Dulaglutide in Type 2 Diabetes: Do GLP-1 agonists delay progression of diabetic nephropathy?

25mm napoleonic british - line 25 figures - inf (33467)

By Connor Emdin
June 27, 2018

Man O War High Elf War Eagles NIB - OOP - Warhammer Manowar Eagle RidersSHATTERED DOMINION LARGE BASE DETAIL - WARHAMMER AOS - GAMES WORKSHOPWarhammer 40,000 Industrial Battlezone - Necromunda Bulkheads Boxed Scenery 40kWarhammer 40k etc , mantic battlezone terrain scenery 25mm napoleonic british - mixed (as photo) - inf (26278)

Procalcitonin-Guided Antibiotic Therapy in Lower Respiratory Tract Infection: Is It Safe?

25mm napoleonic french - dragoons 18 figures - inf (29358)

By Martina McGrath, MD
June 5, 2018

Warhammer 40k Sector Mechanicus Ferratonic Incinerator GWS 64-41 NIBWarhammer Age of Sigmar Skaven Stormvermin GWS 90-07 NIB 25mm napoleonic french - guard 31 figures - inf (31786)

25mm napoleonic french - infantry 42 figs - inf (21421)

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By Lea Borgi, MD
May 16, 2018

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